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As a result, based on phylogeny as Supplementary Fig.S1, Dai from southern China could be considered to be a surrogate of ancestral EAS (Fig. Similarly, we applied our approach for each pair of EUR and found French holds the less genetic contribution from EAS than other EUR, and therefore can be considered as a surrogate of ancestral EUR (Fig. We assumed a Hybrid Isolation (HI) model for admixed Eurasian populations with ancestries from both EUR and EAS, as shown in Supplementary Fig. For each group of EAS, we assessed whether the statistic f), significantly deviates from zero (see Methods). Otherwise, the population should have entire EAS ancestry.We systematically estimated gene flow between Eurasian groups using genome-wide polymorphisms from 34 populations representing Europeans, East Asians, and Central/South Asians.We identified recent gene flow between Europeans and Asians in most populations we studied, including East Asians and Northwestern Europeans, which are normally considered to be non-admixed populations.These studies reported the Asian or American contribution in European populations.

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What have been the biological consequences of these contacts in terms of gene flow?An estimation of admixture proportions for each EAS is provided in Table 2.We detected 2.8 ± 0.2% EUR ancestry in Northern Han Chinese (CHB), which was more than that in Southern Han Chinese (CHS; 1.7 ± 0.1%), Japanese (2.2 ± 0.2%) and Korean (1.6 ± 0.2%) populations.Here we present what is, to the best of our knowledge, a systematic investigation of genetic admixture between different European and Asian populations using genome-wide single nucleotide polymorphism (SNP) data from 34 populations, including seven European groups (EUR), 9 Central or South Asian groups (CSA), and 17 East Asian groups (EAS) and one Tibetan group from Tibet Plateau.Based on statistical analysis using 4 Population Test (f, we detected gene flow between Europeans and Asians were prevalent for most populations including even those from west-northern Europe and East Asia which have been generally regarded as less admixed.

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